mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry
نویسندگان
چکیده
منابع مشابه
mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.
Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated in susceptibility to type 2 diabetes. We describe the ability of mammalian target of rapamycin (mTOR) to regulate the cap-independent translation of IGF2 mRNA through phosphorylation of IMP2, an oncofetal RNA-binding protein. IMP2 is doubly phosphorylated in a rapamycin-inhibitable, amino acid-...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2011
ISSN: 0890-9369
DOI: 10.1101/gad.2042311